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RP-1664

RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.

Product Specifications

CAS Number

2980682-00-4

Product Name Alternative

RP1664

Field of Research

Cell Biology

Purity

99.04% (May vary between batches)

Solubility

DMSO:80 mg/mL (155.48 mM)

Smiles

O=S (=O) (C1=CC (F) =C (C (F) =C1) N (C=2N=C (NC3=NNC (=C3) C) C (=C (N2) C=4N=CN (C4) C) C5CC5) C) C

Molecular Formula

C23H24F2N8O2S

Molecular Weight

514.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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