RP-1664
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. This compound demonstrates exceptional selectivity over related kinases, disrupts centriole biogenesis in cancer cells leading to PLK4 and p21 protein accumulation, shows enhanced sensitivity in TRIM37-high-expressing cells, and exhibits antitumor activity in breast cancer and neuroblastoma research.
Product Specifications
CAS Number
2980682-00-4
Product Name Alternative
RP1664
Field of Research
Cell Biology
Purity
99.04% (May vary between batches)
Solubility
DMSO:80 mg/mL (155.48 mM)
Smiles
O=S (=O) (C1=CC (F) =C (C (F) =C1) N (C=2N=C (NC3=NNC (=C3) C) C (=C (N2) C=4N=CN (C4) C) C5CC5) C) C
Molecular Formula
C23H24F2N8O2S
Molecular Weight
514.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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