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TREK inhibitor-3

TREK inhibitor-3 (Cpd8l) is a selective inhibitor of TREK-1 that can cross the blood-brain barrier, with an IC50 of 0.81 μM. It offers neuroprotective effects by significantly reducing cortical neuron death induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and alleviating brain injury in middle cerebral artery occlusion/reperfusion (MCAO/R) model mice. TREK inhibitor-3 is utilized in ischemic stroke research.

Product Specifications

CAS Number

3023854-95-4

Field of Research

Pharmacology & Drug Discovery, Pharmacology & Drug Discovery; Cell Biology

Smiles

O=C1OC (C2=CC=C (C=C12) C3CCNCC3) CC=4C=CC=CC4C

Molecular Formula

C21H23NO2

Molecular Weight

321.413

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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