Galectin-3-IN-6
Galectin-3-IN-6 (Compound 12) is an orally active galectin-3 (Gal-3) inhibitor, with an IC50 of 12 nM and a Kd of 13 nM for Gal-3. In a CCl4-induced mouse model of acute liver injury and fibrosis, Galectin-3-IN-6 significantly reduces fibrosis markers collagen-1 and α-smooth muscle actin (αSMA) by 64% and 71%, respectively, demonstrating notable anti-fibrotic activity. Galectin-3-IN-6 is applicable for research in fibrosis-related diseases, cancer, and cardiovascular disorders.
Product Specifications
CAS Number
2604662-64-6
Field of Research
Immunology & Inflammation
Smiles
O (C) [C@@H]1[C@H] ([C@@H] (O) [C@@H] (CO) O[C@H]1C (N (C2=CC (Cl) =CC (Cl) =C2) [C@@H]3[C@@H] (O) CCCC3) =O) N4C=C (N=N4) C5=CC (F) =C (F) C (F) =C5
Molecular Formula
C28H29Cl2F3N4O6
Molecular Weight
645.454
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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