α-Tubulin polymerization-IN-1
α-Tubulin polymerization-IN-1 (Compound 8l) functions as an inhibitor of α-tubulin polymerization. This compound modulates the NRF2/KEAP-1 signaling pathway and induces ROS production in PC-3 cells, leading to apoptosis. It inhibits the proliferation of PC-3 cells with a GI50 of 0.17 μM, causing cell cycle arrest in the G2/M phase. Additionally, α-Tubulin polymerization-IN-1 demonstrates antitumor activity in mouse models.
Product Specifications
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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