Brefeldin A 4-O-nicotinate
Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.
Product Specifications
CAS Number
3035018-34-6
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C (=O) C=1C=CC=NC1) [C@H]/2[C@]3 ([C@@] (C[C@H] (O) C3) (/C=C/CCC[C@H] (C) OC (=O) \C=C2) [H]) [H]
Molecular Formula
C22H27NO5
Molecular Weight
385.453
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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