What is the catalog number for R1-ICR-5?

The catalog number for R1-ICR-5 is orb3028478.

What sizes are available for R1-ICR-5?

R1-ICR-5 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does R1-ICR-5 come in?

R1-ICR-5 is available in 2 different pack sizes.

Is R1-ICR-5 in stock?

R1-ICR-5 is currently made to order / not held in immediate stock. Contact us for lead time.

R1-ICR-5

R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1) . Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.

Product Specifications

CAS Number

3070346-91-4

Field of Research

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Smiles

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