Clifutinib
Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.
Product Specifications
CAS Number
1862226-99-0
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NC1=NOC (=C1) C (C) (C) C) NC2=CC=C (C#CC3=CC=C (OCCCN4CCOCC4) C=C3) C=C2
Molecular Formula
C29H34N4O4
Molecular Weight
502.605
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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