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2-Guanidinobezimidazole

2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB) .

Product Specifications

CAS Number

5418-95-1

Field of Research

Immunology & Inflammation

Smiles

N=C (N) NC1=NC=2C=CC=CC2N1

Molecular Formula

C8H9N5

Molecular Weight

175.191

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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