Mal-N (Me) -C6-N (Me) -PNU-159682
Mal-N (Me) -C6-N (Me) -PNU-159682 (Compound 27) is an active molecular conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Mal-N (Me) -C6-N (Me) and the potent cytotoxin PNU-159682. This compound selectively delivers its payload to cells expressing CD46 and releases PNU-159682 through cathepsin B cleavage of the linker, inducing DNA damage and apoptosis. Mal-N (Me) -C6-N (Me) -PNU-159682 has demonstrated sustained tumor regression in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) .
Product Specifications
CAS Number
2682939-57-5
Field of Research
Cell Biology
Smiles
O ([C@@H]1C2=C (C (O) =C3C (=C2O) C (=O) C=4C (C3=O) =CC=CC4OC) C[C@] (C (COC (N (CCCCCCN (C (CN5C (=O) C=CC5=O) =O) C) C) =O) =O) (O) C1) [C@H]6C[C@@]7 (N8[C@] (O[C@@]7 ([C@H] (C) O6) [H]) ([C@@H] (OC) OCC8) [H]) [H]
Molecular Formula
C47H56N4O17
Molecular Weight
948.964
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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