(S, R, S) -AHPC-Boc derivative 1
(S, R, S) -AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1. This interaction leads to the ubiquitination and subsequent proteasomal degradation of MALT1. By disrupting the CBM complex, (S, R, S) -AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway and shows potential in inducing apoptosis in ABC-DLBCL cells. It holds promise for research into MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL) .
Product Specifications
CAS Number
2086298-33-9
Field of Research
Immunology & Inflammation
Smiles
C ([C@@H] (NC (OC (C) (C) C) =O) C (C) (C) C) (=O) N1[C@H] (C (N[C@@H] (CO) C2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1
Molecular Formula
C28H40N4O6S
Molecular Weight
560.705
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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