Antitumor agent-190
Antitumor agent-190 (Compound 26) is a hexokinase 2 (Hexokinase2) inhibitor that exhibits significant antitumor activity by targeting both microtubules and hexokinase 2 (Hexokinase2), with an IC50 value of 0.764 μM against MD-MBA-231 cells. It effectively suppresses Hexokinase2 activity, resulting in the accumulation of reactive oxygen species (Reactive Oxygen Species) and disruption of mitochondrial membrane potential (MMP), thus promoting apoptosis and causing cell cycle arrest.
Product Specifications
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
C1COCCN1C2=CC3=C (C=C2) N (C=C3/C=C/C (=O) C4=CN=CC=C4) S (=O) (=O) C5=CC=C (C=C5) [N+] (=O) [O-]
Molecular Formula
C26H22N4O6S
Molecular Weight
518.541
Storage Conditions
-20°C
Notes
For research use only.
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