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TGFβRI-IN-7

TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.

Product Specifications

Field of Research

Stem Cell & Developmental Biology

Smiles

CN (C) CCN1C=C (C=N1) C2=CC3=NC=CC (=C3C=C2) OC4=CN (N=C4C5CCOCC5) C6CC6

Molecular Formula

C27H32N6O2

Molecular Weight

472.582

Storage Conditions

-20°C

Notes

For research use only.

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