L1BC8
L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer properties. It also serves as a drug-linker conjugate for ADC, suitable for ADC synthesis. The resulting BRD4 degrader antibody conjugates demonstrate potent antigen-dependent BRD4 degradation and antiproliferative activity in cellular assays.
Product Specifications
CAS Number
2417370-68-2
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
C (S (C) (=O) =O) C=1C=C2C=3C=4C (CN (C2=CC1C (NCCOC5=CC (NC (OCC6=CC=C (NC ([C@@H] (NC (=O) C7 (C (NCCCCCN8C (=O) C=CC8=O) =O) CCC7) CCCNC (N) =O) =O) C=C6) =O) =CC (CCOCC (N[C@H] (C (=O) N9[C@H] (C (NCC%10=CC=C (C=C%10) C%11=C (C) N=CS%11) =O) C[C@@H] (O) C9) C (C) (C) C) =O) =C5) =O) C%12=C (F) C=C (F) C=N%12) =CNC4C (=O) N (C) C3
Molecular Formula
C86H98F2N16O18S2
Molecular Weight
1745.92
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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