S118
S118 is an orally active inhibitor of the sphingosine-1-phosphate receptor 2 (S1P2 receptor) . It prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin, and blocks the nuclear translocation of the S1P2 receptor. This process inhibits inflammation, fibrosis, and epithelial-mesenchymal transition (EMT), thereby exhibiting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is considered promising for research in idiopathic pulmonary fibrosis.
Product Specifications
CAS Number
2677041-36-8
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Smiles
O=C (NNC=1N=C2C (C=NN2C) =C (C1) C=3C=CC (F) =CC3) NC=4C=C (Cl) N=C (Cl) C4
Molecular Formula
C19H14Cl2FN7O
Molecular Weight
446.265
Storage Conditions
-20°C
Notes
For research use only.
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