(S) -dHTC1
(S) -dHTC1 is a molecular glue degrader specifically targeting the transcriptional coactivator ENL. It exhibits high affinity binding to E3 ligase only upon formation of the ENL: (S) -dHTC1 complex, with an IC50 of 93 nM. In MV4;11 cells, (S) -dHTC1 degrades ENL with a DC50 of 26 nM. This compound can be utilized for acute myeloid leukemia research.
Product Specifications
CAS Number
3081383-46-9
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1[C@]2 (CN (S (NC3CCN (CCNC (=O) C4=CC (=CC=C4) C5=CN6C (=N5) C=CC (C (NC7CCC7) =O) =C6) CC3) (=O) =O) CC2) CC (=O) N1
Molecular Formula
C33H40N8O6S
Molecular Weight
676.786
Storage Conditions
-20°C
Notes
For research use only.
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