EGFR-IN-159
EGFR-IN-159 (compound 12) is a dihydropyrimidine and a potent EGFR inhibitor with an IC50 of 29.00 nM. It exhibits dose-dependent inhibition of EGFR and HER2. The compound shows cytotoxicity against MCF-7 breast cancer cells and Vero cells with IC50 values of 16.07 μg/mL and 35.98 μg/mL, respectively. EGFR-IN-159 does not cross the blood-brain barrier (BBB) and demonstrates significant anticancer activity.
Product Specifications
CAS Number
2055746-08-0
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1NC (=C (C (=O) NC=2C=CC=CC2OC) C (N1) C3=CC=C (O) C (OCC) =C3) C
Molecular Formula
C21H23N3O5
Molecular Weight
397.424
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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