DNJ-20
DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL. It exhibits broad-spectrum activity against SARS-CoV-2. By interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), DNJ-20 hinders the proper processing of viral glycoproteins, thus blocking the formation and infection of viral particles. It is effective against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43, with IC50 values reaching up to 1.49 μM. DNJ-20 can be utilized for pan-coronavirus research.
Product Specifications
CAS Number
3081926-49-7
Field of Research
Infectious Disease & Virology, Metabolism Research
Smiles
O (CCCCCCCCCCN1[C@H] (CO) [C@@H] (O) [C@H] (O) [C@@H] (O) C1) C2=C3C (OC (=CC3=O) C4=CC (O) =C (O) C=C4) =CC (O) =C2
Molecular Formula
C31H41NO10
Molecular Weight
587.658
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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