PROTAC MNK1 degrader-1
ROTACMNK1degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM and a Dmax greater than 96% in MV4-11 cells. It significantly reduces p-eIF4E levels with an IC50 of 22.07 nM, induces apoptosis, and causes cell cycle arrest at the G1 phase. This compound exhibits potent antitumor activity, demonstrating strong anti-leukemic effects in MV4-11 xenograft mouse models with acceptable drug safety.
Product Specifications
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (C1CCN (C (CCCCCC (NC2=C (CN (C3C (NC (CC3) =O) =O) C4=O) C4=CC=C2) =O) =O) CC1) NC (S5) =NC=C5C6=CC=CC=C6
Molecular Formula
C35H38N6O6S
Molecular Weight
670.78
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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