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IDO1/TDO-IN-8

IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.

Product Specifications

Field of Research

Metabolism Research

Smiles

CC1=CC (C2=NC=CC3=C2NC4=CC=CC=C43) =C (C) S1

Molecular Formula

C17H14N2S

Molecular Weight

278.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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