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Mrgx2 antagonist-3

Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.

Product Specifications

CAS Number

2641397-91-1

Field of Research

Pharmacology & Drug Discovery

Smiles

O=C1C (=C (N=C2NC3=CC (F) =C (F) C=C3N12) C (C) C) CC

Molecular Formula

C15H15F2N3O

Molecular Weight

291.30

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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