SI-W052
SI-W052 is an orally active, brain-penetrant, and selective small molecule inhibitor that targets mTOR and TEX264. It activates autophagy by inhibiting mTOR phosphorylation, enhances TEX264 expression to promote endoplasmic reticulum renewal, and suppresses the release of LPS-induced inflammatory factors (TNF-α, IL-6) . SI-W052 shows potential for research into neuroinflammation associated with Alzheimer's disease (AD) .
Product Specifications
CAS Number
2572552-60-2
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
O=C (O) C1=CC (=C (Cl) C=C1NCC=2OC=CC2) S (=O) (=O) N (C) CC=3C=CC=CC3
Molecular Formula
C20H19ClN2O5S
Molecular Weight
434.89
Storage Conditions
-20°C
Notes
For research use only.
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