HDAC3-IN-7

HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC50 value of 311 nM. It effectively induces the degradation of PD-L1 via a cathepsin B-mediated lysosomal pathway, demonstrating the ability to inhibit tumor cell proliferation, migration, and invasion. HDAC3-IN-7 holds potential for cancer research.