IRAK1/4/pan-FLT3 Kinase-IN-2
IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.
Product Specifications
CAS Number
2760329-44-8
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Cell Biology, Signal Transduction
Smiles
FC1=C (C=2N3C (C=C (OC (C) C) C=C3) =NC2) N=C (N[C@@H]4[C@@H] (F) CCNC4) C (F) =C1
Molecular Formula
C20H22F3N5O
Molecular Weight
405.42
Storage Conditions
-20°C
Notes
For research use only.
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