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IRAK1/4/pan-FLT3 Kinase-IN-2

IRAK1/4/pan-FLT3 Kinase-IN-2 (compound 27) is a potent dual inhibitor of IRAK1/4 and FLT3 with IC50 values of 10 nM, 0.7 nM, and < 0.5 nM, respectively. This compound enhances survival in mice models of acute myeloid leukemia.

Product Specifications

CAS Number

2760329-44-8

Field of Research

Immunology & Inflammation, Immunology & Inflammation; Cell Biology, Signal Transduction

Smiles

FC1=C (C=2N3C (C=C (OC (C) C) C=C3) =NC2) N=C (N[C@@H]4[C@@H] (F) CCNC4) C (F) =C1

Molecular Formula

C20H22F3N5O

Molecular Weight

405.42

Storage Conditions

-20°C

Notes

For research use only.

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