(3S) -Tanzisertib hydrochloride
(3S) -Tanzisertib (hydrochloride) ((3S) -CC-930 (hydrochloride) ) is an orally active JNK inhibitor, exhibiting IC50 values of 61 nM for JNK1, 7 nM for JNK2, and 6 nM for JNK3. It selectively inhibits ERK1, p38α, and EGFR, with IC50 values of 0.48 μM, 3.4 μM, and 0.38 μM, respectively. In an acute rat PK-PD model, (3S) -Tanzisertib (hydrochloride) suppresses LPS-induced TNFα production and is utilized in research on idiopathic pulmonary fibrosis (IPF) .
Product Specifications
CAS Number
2517855-91-1
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
N (C=1N (C=2C (N1) =CN=C (NC3CCC (O) CC3) N2) [C@H]4CCOC4) C5=C (F) C=C (F) C=C5F.Cl
Molecular Formula
C21H24ClF3N6O2
Molecular Weight
484.90
Storage Conditions
-20°C
Notes
For research use only.
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