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Nav1.2-IN-1

Nav1.2-IN-1 (compound 5i) is a 3- (1,2,3,6-tetrahydropyridine) -4-azaindole derivative that acts as a potent and selective Nav1.2 inhibitor. It effectively reduces the peak current of Nav1.2 with an IC50 of 7.79 μM. Nav1.2-IN-1 demonstrates antiepileptic activity and shows strong anticonvulsant effects with low neurotoxicity in a subcutaneous pentylenetetrazol (sc-PTZ) induced seizure model.

Product Specifications

CAS Number

3084825-09-9

Field of Research

Pharmacology & Drug Discovery

Molecular Formula

C20H18F3N3

Storage Conditions

-20°C

Notes

For research use only.

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