Dopamine D4 receptor ligand 3
Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.
Product Specifications
CAS Number
3082344-46-2
Field of Research
Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (O) C (=O) O.O=C1N (C=2C=CC=CC2CC1) CCCN3CCN (C=4C=CC=5C=CC=CC5C4) CC3
Molecular Formula
C28H31N3O5
Molecular Weight
489.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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