Aurora kinase inhibitor-14
Aurora kinase inhibitor-14 (Compound 79) is an orally active and highly selective inhibitor of Aurora kinases, effectively inhibiting both Aurora A and Aurora B with IC50 values of 0.5 nM and 1.2 nM, respectively. It binds to the ATP binding site of Aurora kinases, blocking chromosome separation during mitosis and inducing apoptosis in tumor cells. Aurora kinase inhibitor-14 shows potential for research in various solid tumors and hematologic malignancies, such as non-small cell lung cancer, breast cancer, and acute myeloid leukemia.
Product Specifications
CAS Number
958226-81-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
N (C=1C (C (F) (F) F) =CN=C (NC2=CC=C (C (N (C) C3CCN (C) CC3) =O) C=C2) N1) [C@H]4C[C@@H] (C (NC (C) C) =O) CC4
Molecular Formula
C28H38F3N7O2
Molecular Weight
561.64
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Histone H1 (AE-4), CF594 conjugate, 0.1mg/mL
CD44 Standard (DF1485), CF405M conjugate, 0.1mg/mL
CD31 / PECAM-1 (158-2B3), CF647 conjugate, 0.1mg/mL
Cytokeratin 3 (KRT3) (Corneal Epithelial Marker) (KRT3/2130), CF640R conjugate, 0.1mg/mL
