PI3K-IN-58
PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.
Product Specifications
CAS Number
3067572-78-2
Field of Research
Cell Biology, Signal Transduction
Smiles
C (=C/C (NCCO) =O) \C=1SC2=C (N=C (N=C2C1) C3=C4C (=CC=C3) NN=C4) N5CCOCC5
Molecular Formula
C22H22N6O3S
Molecular Weight
450.51
Storage Conditions
-20°C
Notes
For research use only.
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