(2S,3S,11bR) -Dihydrotetrabenazine

(2S,3S,11bR) -Dihydrotetrabenazine ((2S,3S,11bR) -DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. It suppresses the vesicular transport of monoamine neurotransmitters, such as dopamine and serotonin, leading to reduced release into the synaptic cleft. This compound holds potential for research in Huntington's disease and other hyperkinetic movement disorders.