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GSK-3α/β-IN-1

GSK-3α/β-IN-1 is a GSK-3α/β inhibitor with IC50 values of 0.265 μM for GSK-3α and 0.255 μM for GSK-3β. It also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 effectively reduces cell viability in three glioblastoma (GBM) cell lines (IC50: 3-6 μM over 72 hours) without being toxic to human astrocytes, and it exhibits good metabolic stability. Additionally, it shows potential central nervous system activity in a whole human blood-brain barrier (BBB) GBM model.

Product Specifications

CAS Number

1574354-24-7

Field of Research

Signal Transduction, Stem Cell & Developmental Biology

Smiles

OC=1C=CC2=C (OC3=C2NC4=NN=CC4=C3C=5C=CC (=CC5) C (C) C) C1

Molecular Formula

C21H17N3O2

Molecular Weight

343.38

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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