CDK9/EZH2-IN-1
CDK9/EZH2-IN-1 is a dual-target inhibitor of CDK9 and EZH2 with IC50 values of 83.9 nM and 108.6 nM, respectively. It induces apoptosis and causes DNA double-strand breaks (DSB) . Additionally, CDK9/EZH2-IN-1 inhibits the proliferation of MKN45, MDA-MB-453, and SW620 cancer cells, with respective IC50 values of 136.3 nM, 171.3 nM, and 315.7 nM.
Product Specifications
CAS Number
3081246-18-3
Field of Research
Cell Biology, Epigenetics & Chromatin
Smiles
O=C (NCC=1C (=O) NC (=CC1C) C) C2=CC (=CC3=C2C=NN3C (C) C) C=4C=NC (=CC4) N5CCN (CC5) CCN6CCC (C (=O) NC7=NC=C (S7) SCC8=NC=C (O8) C (C) (C) C) CC6
Molecular Formula
C47H59N11O4S2
Molecular Weight
906.17
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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