PI3K-IN-59

PI3K-IN-59 (Compound 3d) is a PI3K inhibitor with an IC50 value of 17.44 μM. It demonstrates significant antiproliferative activity, showing potent inhibition against breast cancer 4T1 cells (IC50: 3.70 μM), colon cancer CT26 cells (IC50: 1.98 μM), and human breast cancer cells (IC50: 19.72 μM) . The compound operates through a dual antitumor mechanism by inhibiting PI3Kα enzymatic activity and inducing hydroxyl radical (•OH) generation via the Fenton reaction. PI3K-IN-59 shows promising efficacy against 4T1 tumors, making it suitable for synergistic targeting studies in breast and colon cancer.