JS25

Product Specifications

UNSPSC Description

JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier[1].

Target Antigen

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/js25.html

Solubility

DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

C=CC(NC1=CC(C)=CC(N2C(C=CC3=C2C4=C(N=C3)C=C(C=C4)C5=CC=C(C=C5)NS(C)(=O)=O)=O)=C1)=O

Molecular Weight

524.59

References & Citations

[1]Sousa B B, et al. Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors[J]. ACS Pharmacology & Translational Science, 2022.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-151808/JS25-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-151808/JS25-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2411771-95-2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-25028JF635 0.1 mL

Mouse Monoclonal 53BP1 Antibody (6B3E10) [Janelia Fluor 635]

Ask

View Details

RC209990L2 10 µg

RPL13A (NM_012423) Human Tagged Lenti ORF Clone

Ask