PROTAC STING degrader-4
PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI) .
Product Specifications
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction
Molecular Formula
C39H42Cl2N8O9
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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