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PROTAC STING degrader-4

PROTACSTING degrader-4 is a covalent STINGPROTAC degrader free of nitro groups, exhibiting a DC50 of 3.23 μM. It effectively inhibits STING and its downstream signaling pathways, including p-TBK1 and p-NF-κB (p-P65), as well as immune-inflammatory cytokines. Additionally, PROTACSTING degrader-4 mitigates renal and blood inflammation in mouse models of Cisplatin-induced acute kidney injury (AKI) .

Product Specifications

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Molecular Formula

C39H42Cl2N8O9

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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