TrxR-IN-8
TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.
Product Specifications
CAS Number
2857180-28-8
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
[I-].O (C=1C=C (OC) C=2C=3C=CC=CC3C=[N+] (C2C1) C) C
Molecular Formula
C16H16INO2
Molecular Weight
381.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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