TrxR-IN-8
TrxR-IN-8 (Compound 6f) is a selective inhibitor of TrxR with an IC50 of 10.2 μM. It induces apoptosis through oxidative stress by stimulating the production of reactive oxygen species, reducing intracellular thiols, and lowering the glutathione/glutathione disulfide ratio. TrxR-IN-8 exhibits significant cytotoxicity against non-small cell lung cancer (NSCLC) cells.
Product Specifications
CAS Number
2857180-28-8
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
[I-].O (C=1C=C (OC) C=2C=3C=CC=CC3C=[N+] (C2C1) C) C
Molecular Formula
C16H16INO2
Molecular Weight
381.21
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400049-500 1x 500 µL
CD31 / PECAM-1 (C31.3), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
OR1052922-01 50 mg
7-Methoxy-8-methyl-3,4-dihydronaphthalen-1 (2H) -one
Sign In for Pricing
View Details OR1052922-02 100 mg
7-Methoxy-8-methyl-3,4-dihydronaphthalen-1 (2H) -one
Sign In for Pricing
View Details 
OR1052922-03 250 mg
7-Methoxy-8-methyl-3,4-dihydronaphthalen-1 (2H) -one
Sign In for Pricing
View Details