EZH2/HSP90-IN-29
EZH2/HSP90-IN-29 is a potent dual inhibitor of EZH2 and HSP90, with IC50 values of 6.29 nM and 60.1 nM, respectively. It induces cell cycle arrest at the M phase, promotes the expression of genes related to apoptosis/necrosis, and inhibits reactive oxygen species (ROS) catabolism. This compound can cross the blood-brain barrier, making it a promising and easily manageable candidate for glioblastoma (GBM) research.
Product Specifications
CAS Number
3033571-35-3
Field of Research
Epigenetics & Chromatin
Smiles
O=C (NCC=1C (=O) NC (=CC1C) C) C=2C=C (C=C (C2C) N (CC) C3CCOCC3) C=4C=CC=C (C4) N (C (=O) C=5C=C (C (O) =CC5O) C (C) C) C
Molecular Formula
C40H48N4O6
Molecular Weight
680.83
Storage Conditions
-20°C
Notes
For research use only.
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