Z57346765 hydrochloride
Z57346765 hydrochloride is an inhibitor of phosphoglycerate kinase 1 (PGK1) that binds to the ADP binding site, with a K\ (_D\) value of 2.09 x 10−5 M, thereby reducing the metabolic enzyme activity of PGK1, glucose consumption, and lactate production. Additionally, it inhibits DNA replication, impairs DNA damage repair, and induces cell cycle arrest in renal clear cell carcinoma (KIRC) cells.
Product Specifications
Smiles
OCCNC1=NC (NC2=CC=C (C) C=C2) =NC3=CC=CC=C31.Cl
Molecular Formula
C17H19ClN4O
Molecular Weight
330.81
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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