Trimetazidine
Trimetazidine is a non-haemodynamic antianginal agent that selectively inhibits the mitochondrial enzyme 3-ketoacyl coenzyme A thiolase (LC 3-KAT), thereby preventing β-oxidation of free fatty acids, with an IC50 value of 75 nM. Trimetazidine prevents ischaemia-reperfusion injury by altering cardiac metabolism, exhibiting antioxidant and anti-ischaemic effects.
Product Specifications
CAS Number
5011-34-7
Product Name Alternative
Trimetazidine
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Purity
99.90% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.39 mM) ; DMSO:85 mg/mL (319.14 mM)
Smiles
COc1ccc (CN2CCNCC2) c (OC) c1OC
Molecular Formula
C14H22N2O3
Molecular Weight
266.34
Storage Conditions
-20°C
Notes
For research use only.
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