CHMFL-FLT3-122
CHMFL-FLT3-122 is a potent and orally available FLT3 kinase inhibitor used to treat FLT3-ITD positive acute myeloid leukemia. CHMFL-FLT3-122 significantly suppressed the tumor growth in MV4-11 cell inoculated xenograft model (50 mg/kg) without exhibiting obvious toxicity in vivo.
Product Specifications
CAS Number
1839150-56-9
Product Name Alternative
FLT3 (ITD), CHMFL FLT3 122, CHMFLFLT 3122, CHMFLFLT3122, CHMFL-FLT3-122, CHMFLFLT-3122
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.56% (May vary between batches)
Solubility
DMSO:90 mg/mL (190.86 mM) ;1eq. HCl:90 mg/mL (190.86 mM)
Smiles
NC1=C2C (N (N=C2C3=CC=C (OC4=CC=CC=C4) C=C3) [C@H]5CN (C (CN (C) C) =O) CCC5) =NC=N1
Molecular Formula
C26H29N7O2
Molecular Weight
471.55
Storage Conditions
-20°C
Notes
For research use only.
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