NBI-74330
NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum.
Product Specifications
CAS Number
855527-92-3
Product Name Alternative
NBI74330
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
99.37% (May vary between batches)
Solubility
DMSO:80 mg/mL (132.1 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (5.45 mM)
Smiles
[C@@H] (N (CC=1C=CC=NC1) C (CC2=CC (C (F) (F) F) =C (F) C=C2) =O) (C) C=3N (C (=O) C=4C (N3) =NC=CC4) C5=CC=C (OCC) C=C5
Molecular Formula
C32H27F4N5O3
Molecular Weight
605.58
Storage Conditions
-20°C
Notes
For research use only.
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