IKIX1
IKIX1 is an antifungal agent and resensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC50 and Ki values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection[1].
Product Specifications
CAS Number
656222-54-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ikix1.html
Purity
99.76
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NNC(NC1=CC=C(Cl)C(Cl)=C1)=S)CC#N
Molecular Formula
C10H8Cl2N4OS
Molecular Weight
303.17
Precautions
H315, H319, H335
References & Citations
[1]Joy L Nishikawa, et al.Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25;530 (7591) :485-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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