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GDC-2394 sodium salt

GDC-2394 sodium salt is an orally active selective NLRP3 inhibitor that concurrently inhibits IL-1β with IC50 values of 0.4 μM (human) and 0.1 μM (mouse) . This compound specifically inhibits NLRP3-induced caspase-1 activity without affecting NLRC4-dependent inflammasome activation.

Product Specifications

CAS Number

2238822-08-5

Product Name Alternative

GDC2394 sodium salt

Field of Research

Immunology & Inflammation, Signal Transduction

Purity

99.50% (May vary between batches)

Smiles

[Na+].CN[C@@H]1COC2=C (C=NN2C1) S (=O) (=O) [N-]C (=O) NC1=C2CCCC2=CC2=C1CCC2

Molecular Formula

C20H24N5NaO4S

Molecular Weight

453.49

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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