GDC-2394 sodium salt
GDC-2394 sodium salt is an orally active selective NLRP3 inhibitor that concurrently inhibits IL-1β with IC50 values of 0.4 μM (human) and 0.1 μM (mouse) . This compound specifically inhibits NLRP3-induced caspase-1 activity without affecting NLRC4-dependent inflammasome activation.
Product Specifications
CAS Number
2238822-08-5
Product Name Alternative
GDC2394 sodium salt
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
99.50% (May vary between batches)
Smiles
[Na+].CN[C@@H]1COC2=C (C=NN2C1) S (=O) (=O) [N-]C (=O) NC1=C2CCCC2=CC2=C1CCC2
Molecular Formula
C20H24N5NaO4S
Molecular Weight
453.49
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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