Sotuletinib hydrochloride
Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC) .
Product Specifications
CAS Number
2222138-31-8
Field of Research
Signal Transduction
Purity
98.81% (May vary between batches)
Solubility
DMSO:80 mg/mL (183.93 mM) ; H2O:80 mg/mL (183.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.59 mM)
Smiles
N (C=1SC=2C (N1) =CC=C (OC=3C=C (C (NC) =O) N=CC3) C2) [C@H]4[C@H] (O) CCCC4.Cl
Molecular Formula
C20H23ClN4O3S
Molecular Weight
434.94
Storage Conditions
-20°C
Notes
For research use only.
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