SR12343
SR12343 is a small molecule inhibitor of the IKK/NF-κB signaling pathway that functions as a NEMO-binding domain (NBD) mimetic. SR12343 inhibits NF-κB activation with an IC50 of 37.02 μM by specifically blocking the critical IKKβ-NEMO interaction, reduces pulmonary inflammation in models, and is suitable for research into inflammatory and degenerative diseases.
Product Specifications
CAS Number
2055101-86-3
Product Name Alternative
SR 12343
Field of Research
Signal Transduction
Purity
99.91% (May vary between batches)
Solubility
DMSO:80 mg/mL (217 mM)
Smiles
O=C (NCCC=1C=CC=C (Br) C1) CNC2=NC=C (Cl) C=C2
Molecular Formula
C15H15BrClN3O
Molecular Weight
368.66
Storage Conditions
-20°C
Notes
For research use only.
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