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SR12343

SR12343 is a small molecule inhibitor of the IKK/NF-κB signaling pathway that functions as a NEMO-binding domain (NBD) mimetic. SR12343 inhibits NF-κB activation with an IC50 of 37.02 μM by specifically blocking the critical IKKβ-NEMO interaction, reduces pulmonary inflammation in models, and is suitable for research into inflammatory and degenerative diseases.

Product Specifications

CAS Number

2055101-86-3

Product Name Alternative

SR 12343

Field of Research

Signal Transduction

Purity

99.91% (May vary between batches)

Solubility

DMSO:80 mg/mL (217 mM)

Smiles

O=C (NCCC=1C=CC=C (Br) C1) CNC2=NC=C (Cl) C=C2

Molecular Formula

C15H15BrClN3O

Molecular Weight

368.66

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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