AZD1981

AZD1981 is the antagonist for GPR44 (also known also PTGDR2, DP2 or CRTh) . AZD1981 blocks the binding of PGD2 to CRTH2. AZD1981 exhibits immunomodulatory effects and can be used in research of chronic spontaneous urticaria[1][2].

Product Specifications

CAS Number

[802904-66-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CRTH2 (GPR44) ; Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/AZD1981.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CN1C(C)=C(SC2=CC=C(Cl)C=C2)C3=C1C=CC=C3NC(C)=O

Molecular Formula

C19H17ClN2O3S

Molecular Weight

388.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Hu S, et al., PGD2 displays distinct effects in diffuse large B-cell lymphoma depending on different concentrations. Cell Death Discov. 2023 Feb 1;9 (1) :39.|[2]Oliver ET, et al., Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria. Int Arch Allergy Immunol. 2019;179 (1) :21-30.